|
KMID : 0043320070300010022
|
|
Archives of Pharmacal Research
2007 Volume.30 No. 1 p.22 ~ p.27
|
|
|
A Concise Synthesis of a Promising Protein Kinase C Inhibitor: D-erythro-Sphingosine
|
|
Pham Van-Thoai
Joo Jae-Eun
Tian Yong-Shou
Oh Chang-Young
Ham Won-Hun
|
|
|
Abstract
|
|
|
|
In this study, we explored a convenient and concise route for synthesis of D-erythro-sphingosine 1 from commercially available and cheap L-serine. The key steps are simple preparation of amino ketone 5 from Weinreb amide 3 and high diastereoselective reduction of amino ketone 5 to give the natural erythro-(anti-) isomer.
|
|
|
KEYWORD
|
|
|
Sphingolipid, Sphingosine, Ceramide, Amino alcohol
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
  
|